orend tme group
Orend TME Group

Latest News

The TME Group

LEADER. Gertraud Orend had studied Genetics, Biochmemistry, Pharmacology and Organic Chemistry and is currently leading the OREND-Tumor MicroEnvironment Group in an INSERM unit in Strasbourg. 

Group Members

CURRENT MEMBERS. Traditionally The TME Group is an English-speaking laboratory with an international spirit as current and past members derive from across the world.

Research

RESEARCH PROJECT. Tissue homeostasis is highly regulated and when uncontrolled can cause severe life threatening diseases such as chronic inflammation, myocarditis, kidney failure and cancer.

Publications

Selected original articles

Loustau T*, Abou-Faycal C*, Erne W*, Abel zur Wiesch P*, Ksouri A, Imhof T, Mörgelin M, Li C, Mathieu M, Salomé N, Crémel G, Dhaouadi S, Bouhaouala-Zahar B, Koch M, Orend G, Modulating tenascin-C functions by targeting the MAtrix REgulating MOtif, “MAREMO”. 2022. Matrix Biol, 108, 20-38. doi: 10.1016/j.matbio.2022.02.007. PMID: 35227929.

Orend G, Tucker RP, 2021. Did Tenascin-C Co-Evolve With the General Immune System of Vertebrates? Front Immunology, special issue on “Tenascins: Key Players in Tissue Homeostasis and Defense”, guest editors, K. Midwood, G. Orend, K. Imanaka-Yoshida. 12: 663902.

Spenlé C, Loustau T, Burckel H, Riegel G, Abou-Faycal C, Chengbei L, Yilmaz A, Petti L, Steinbach F, Ahowesso C, Jost C, Paul N, Carapito R, Noël G, Anjuère F, Salomé N, Orend G, 2021. Impact of tenascin-C on radiotherapy in a novel syngeneic oral squamous cell carcinoma model with spontaneous dissemination to the lymph nodes, Front Immunology, Special issue on “Tenascins: Key Players in Tissue Homeostasis and Defense”, guest editors, K. Midwood, G. Orend, K. Imanaka-Yoshida, published 5. 7. 2021, doi: 10.3389/fimmu.2021.636108.

Meijer M, de Vos AF, Sengers HP, Scicluna B, Roelofs J, Abou Fayçal C, Uhel F, Orend G, van der Poll T, 2021. Tenascin-C has a modest protective effect on acute lung pathology during methicillin-resistant Staphylococcus aureus-induced pneumonia in mice, Microbiology spectrum, accepted.

Murdamoothoo D, Sun Z, Yilmaz A, Deligne C, Velazquez-Quesada I, Erne W, Nascimento M, Mörgelin M, Cremel G, Paul N, Carapito R, Abou-Faycal C, Midwood K, Loustau T, Orend G, 2021. Immobilization of infiltrating cytotoxic T lymphocytes by tenascin-C and CXCL12 enhances lung metastasis, EMBO Mol Med, 13(6): e13270. Recommended by Faculty Opinions, 2% best papers in Cell biology (https://facultyopinions.com).

Dhaouadi S, Benabderrazek R, Loustau T, Abou-Faycal C, Ksouri A, Erne W, Murdamoothoo D, Mörgelin M, Kungl A, Jung A, Ledrappier S, Benlasfar Z, Bichet S, Chiquet-Ehrismann R†, Hendaoui I, Orend G, Bouhaouala-Zahar B, 2021. Novel human tenascin-C function-blocking camel single domain nanobodies, Front Immunology, Special issue on “Tenascins: Key Players in Tissue Homeostasis and Defense”, guest editors, K. Midwood, G. Orend, K. Imanaka-Yoshida, 12:635166.

Meijer MT, de Vos AF, Scicluna BP, Roelofs JL, Abou Fayçal C, Orend G, Uhel F, van der Poll T, 2021. Tenascin-C Deficiency Is Associated With Reduced Bacterial Outgrowth During Klebsiella pneumoniae-Evoked Pneumosepsis in Mice. Front Immunology, Special issue on “Tenascins: Key Players in Tissue Homeostasis and Defense”, guest editors, K. Midwood, G. Orend, K. Imanaka-Yoshida, 12:600979.

Albacete-Albacete L, Navarro-Lérida I, López JA, Martín-Padura I, Astudillo AM, Ferrarini A, Van-der-Heyden M, Balsinde J, Orend G, Vázquez J, del Pozo MA, ECM deposition is driven by caveolin1-dependent regulation of exosomal biogenesis and cargo sorting. J Cell Biol, 219(11):e202006178.

Spenlé C*, Loustau T*, Murdamoothoo D, Erne W, Beghelli-de la Forest  Divonne S, Veber R, Petti L, Bourdely P, Mörgelin M, Brauchle EM, Cremel G, Randrianarisoa V, Camara A, Rekima S, Schaub S, Nouhen K, Imhof T, Hansen U, Paul N, Carapito R, Pythoud N, Hirschler A, Carapito C, Dumortier H, Mueller CG, Koch M, Schenke-Layland K, Kon S, Sudaka A, Anjuère F, Van Obberghen-Schilling E, Orend G. 2020. Tenascin-C orchestrates an immuno-suppressive microenvironment in oral squamous cell carcinoma, Cancer Immun Res, 8:1122-1138.

Spenlé C*, Loustau T*, Murdamoothoo D, Erne W, Beghelli-de la Forest  Divonne S, Veber R, Petti L, Bourdely P, Mörgelin M, Brauchle EM, Cremel G, Randrianarisoa V, Camara A, Rekima S, Schaub S, Nouhen K, Imhof T, Hansen U, Paul N, Carapito R, Pythoud N, Hirschler A, Carapito C, Dumortier H, Mueller CG, Koch M, Schenke-Layland K, Kon S, Sudaka A, Anjuère F, Van Obberghen-Schilling E, Orend G. 2020. Tenascin-C orchestrates an immuno-suppressive microenvironment in oral squamous cell carcinoma, Cancer Immun Res, 8:1122-1138.

Dhaouadi S, Murdamoothoo D, Asma Tounsi A, William Erne W, Benabderrazek R, Benlasfar Z, Hendaoui L, Chiquet-Ehrismann R, Boubaker S, Orend G, Hendaoui I, Bouhaouala-Zahar B. 2020. Generation and characterization of dromedary Tenascin-C and Tenascin-W specific antibodies. Biochem Biophys Res Comm, https://doi.org/10.1016/j.bbrc.2020.05.077

Deligne C, Murdamoothoo D, Gammage A, Gschwandtner M, Erne W, Loustau T, Marzeda AM, Velazquez-Quesada I, Mazzier I, Sun Z, Orend G and Midwood KS. 2020. Matrix-targeting immunotherapy controls tumor growth and spread by switching macrophage phenotype, Cancer Immun Res 8, 368 – 382.

Gamper C, Spenlé C, Boscá S, van der Heyden M, Erhardt M, Orend G, Bagnard D*, Heinlein M*, 2019, Functionalized Tobacco Mosaic Virus Coat Protein Monomers and Oligomers as Nanocarriers for Anti-Cancer Peptides, Cancers 11, 1609.

Sun Z, Velázquez-Quesada I, Murdamoothoo D, Ahowesso C, Yilmaz A, Spenlé C, Averous G, Erne W, Oberndorfer F, Oszwald A, Kain R, Bourdon C, Mangin P, Deligne C, Midwood K, Abou-Faycal C, Lefebvre O, Klein A, van der Heyden M, Chenard MP, Christofori G, Mathelin C, Loustau T, Hussenet T, Orend G*, 2019. Tenascin-C increases lung metastasis by impacting blood vessel invasions. Matrix Biol. 83, 26 – 47.

Murdamoothoo D, Schwenzer A, Kant J, Rupp T, Marzeda A, Kim Midwood K* and Orend G*, 2018, Investigating cell type specific functions of tenascin-C. Methods in Extracellular Matrix Biology. 143:401-428.