orend tme group
Orend TME Group

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The TME Group

LEADER. Gertraud Orend had studied Genetics, Biochmemistry, Pharmacology and Organic Chemistry and is currently leading the OREND-Tumor MicroEnvironment Group in an INSERM unit in Strasbourg. 

Group Members

CURRENT MEMBERS. Traditionally The TME Group is an English-speaking laboratory with an international spirit as current and past members derive from across the world.


RESEARCH PROJECT. Tissue homeostasis is highly regulated and when uncontrolled can cause severe life threatening diseases such as chronic inflammation, myocarditis, kidney failure and cancer.


Selected articles

Benn MC, Pot SA, Moeller J, Yamashita T, Fonta CM, Orend G, Kollmannsberger P, Vogel V. 2023. How the mechanobiology orchestrates the iterative and reciprocal ECM-cell crosstalk that drives microtissue growth, Science Advances 9, eadd9275 (2023)

Fonta CM, Loustau TLi CPoilil Surendran S, Hansen U, Murdamoothoo D, Benn MC, Velazquez-Quesada I, Carapito R, Orend G*, Vogel V*. Infiltrating CD8+ T cells and M2 macrophages are retained in tumor matrix tracks enriched in low tension fibronectin fibers. Matrix Biol, 116, 1-27doi: 10.1016/j.matbio.2023.01.002. PMID: 36669744

De Cauwer A, Loustau T, Erne W, Pichot A, Molitor A, Stemmelen T, Carapito R, Orend G, Bahram S, Georgel P. Dicer1 deficient mice exhibit premature ageing and metabolic perturbations in adipocytes. 2022. iScience doi.org/10.1016/j.isci.2022.105149

Yilmaz A*, Loustau T*, Salomé N, Poilil Surendran S, Li C, Tucker RP, Izzi V, Lamba R, Koch M, Orend G*, Advances on the roles of tenascin-C in cancer, 2022. J Cell Sci, 135(18): jcs260244. DOI: 10.1242/jcs.260244

Abou-Faycal C, Oszwald A, Feilen T, Contreras MJC, Schilling O, Loustau T, Steinbach F, Schachner H, Langer B, Heeringa P, Rees AJ, Orend G, Kain R. 2022. An adapted passive model of anti-MPO dependent crescentic glomerulonephritis reveals matrix dysregulation and is amenable to modulation by CXCR4 inhibition. Matrix Biol. doi: 10.1016/j.matbio.2022.01.001. PMID: 35032611

Imanaka Yoshida K*, Midwood K*, Orend G*, 2022, Editorial on special issue on Tenascins: Key Players in Tissue Homeostasis and Defense”, Front Immunol, 12, 834353. doi: 10.3389/fimmu.2021.834353. 22 articles with over 61`000 views (18.5.2022).

Loustau T*, Abou-Faycal C*, Erne W*, Abel zur Wiesch P*, Ksouri A, Imhof T, Mörgelin M, Li C, Mathieu M, Salomé N, Crémel G, Dhaouadi S, Bouhaouala-Zahar B, Koch M, Orend G, Modulating tenascin-C functions by targeting the MAtrix REgulating MOtif, “MAREMO”. 2022. Matrix Biol, 108, 20-38. doi: 10.1016/j.matbio.2022.02.007. PMID: 35227929.

Orend G, Tucker RP, 2021. Did Tenascin-C Co-Evolve With the General Immune System of Vertebrates? Front Immunology, special issue on “Tenascins: Key Players in Tissue Homeostasis and Defense”, guest editors, K. Midwood, G. Orend, K. Imanaka-Yoshida. 12: 663902.

Spenlé C, Loustau T, Burckel H, Riegel G, Abou-Faycal C, Chengbei L, Yilmaz A, Petti L, Steinbach F, Ahowesso C, Jost C, Paul N, Carapito R, Noël G, Anjuère F, Salomé N, Orend G, 2021. Impact of tenascin-C on radiotherapy in a novel syngeneic oral squamous cell carcinoma model with spontaneous dissemination to the lymph nodes, Front Immunology, Special issue on “Tenascins: Key Players in Tissue Homeostasis and Defense”, guest editors, K. Midwood, G. Orend, K. Imanaka-Yoshida, published 5. 7. 2021, doi: 10.3389/fimmu.2021.636108.

Meijer M, de Vos AF, Sengers HP, Scicluna B, Roelofs J, Abou Fayçal C, Uhel F, Orend G, van der Poll T, 2021. Tenascin-C has a modest protective effect on acute lung pathology during methicillin-resistant Staphylococcus aureus-induced pneumonia in mice, Microbiology spectrum, 9(1): e0020721. doi: 10.1128/Spectrum.00207-21. PMID: 34319124

Murdamoothoo D, Sun Z, Yilmaz A, Deligne C, Velazquez-Quesada I, Erne W, Nascimento M, Mörgelin M, Cremel G, Paul N, Carapito R, Abou-Faycal C, Midwood K, Loustau T, Orend G, 2021. Immobilization of infiltrating cytotoxic T lymphocytes by tenascin-C and CXCL12 enhances lung metastasis, EMBO Mol Med, 13(6): e13270. Recommended by Faculty Opinions, 2% best papers in Cell biology (https://facultyopinions.com).

Dhaouadi S, Benabderrazek R, Loustau T, Abou-Faycal C, Ksouri A, Erne W, Murdamoothoo D, Mörgelin M, Kungl A, Jung A, Ledrappier S, Benlasfar Z, Bichet S, Chiquet-Ehrismann R†, Hendaoui I, Orend G, Bouhaouala-Zahar B, 2021. Novel human tenascin-C function-blocking camel single domain nanobodies, Front Immunology, Special issue on “Tenascins: Key Players in Tissue Homeostasis and Defense”, guest editors, K. Midwood, G. Orend, K. Imanaka-Yoshida, 12:635166.

Meijer MT, de Vos AF, Scicluna BP, Roelofs JL, Abou Fayçal C, Orend G, Uhel F, van der Poll T, 2021. Tenascin-C Deficiency Is Associated With Reduced Bacterial Outgrowth During Klebsiella pneumoniae-Evoked Pneumosepsis in Mice. Front Immunology, Special issue on “Tenascins: Key Players in Tissue Homeostasis and Defense”, guest editors, K. Midwood, G. Orend, K. Imanaka-Yoshida, 12:600979.

Albacete-Albacete L, Navarro-Lérida I, López JA, Martín-Padura I, Astudillo AM, Ferrarini A, Van-der-Heyden M, Balsinde J, Orend G, Vázquez J, del Pozo MA, ECM deposition is driven by caveolin1-dependent regulation of exosomal biogenesis and cargo sorting. J Cell Biol, 219(11): e202006178.

Spenlé C*, Loustau T*, Murdamoothoo D, Erne W, Beghelli-de la Forest  Divonne S, Veber R, Petti L, Bourdely P, Mörgelin M, Brauchle EM, Cremel G, Randrianarisoa V, Camara A, Rekima S, Schaub S, Nouhen K, Imhof T, Hansen U, Paul N, Carapito R, Pythoud N, Hirschler A, Carapito C, Dumortier H, Mueller CG, Koch M, Schenke-Layland K, Kon S, Sudaka A, Anjuère F, Van Obberghen-Schilling E, Orend G. 2020. Tenascin-C orchestrates an immuno-suppressive microenvironment in oral squamous cell carcinoma, Cancer Immun Res, 8: 1122-1138.

Dhaouadi S, Murdamoothoo D, Asma Tounsi A, William Erne W, Benabderrazek R, Benlasfar Z, Hendaoui L, Chiquet-Ehrismann R, Boubaker S, Orend G, Hendaoui I, Bouhaouala-Zahar B. 2020. Generation and characterization of dromedary Tenascin-C and Tenascin-W specific antibodies. Biochem Biophys Res Commhttps://doi.org/10.1016/j.bbrc.2020.05.077

Deligne C, Murdamoothoo D, Gammage A, Gschwandtner M, Erne W, Loustau T, Marzeda AM, Velazquez-Quesada I, Mazzier I, Sun Z, Orend G and Midwood KS. 2020. Matrix-targeting immunotherapy controls tumor growth and spread by switching macrophage phenotype, Cancer Immun Res 8, 368 – 382.